107 research outputs found
Evaluating true BCI communication rate through mutual information and language models.
Brain-computer interface (BCI) systems are a promising means for restoring communication to patients suffering from "locked-in" syndrome. Research to improve system performance primarily focuses on means to overcome the low signal to noise ratio of electroencephalogric (EEG) recordings. However, the literature and methods are difficult to compare due to the array of evaluation metrics and assumptions underlying them, including that: 1) all characters are equally probable, 2) character selection is memoryless, and 3) errors occur completely at random. The standardization of evaluation metrics that more accurately reflect the amount of information contained in BCI language output is critical to make progress. We present a mutual information-based metric that incorporates prior information and a model of systematic errors. The parameters of a system used in one study were re-optimized, showing that the metric used in optimization significantly affects the parameter values chosen and the resulting system performance. The results of 11 BCI communication studies were then evaluated using different metrics, including those previously used in BCI literature and the newly advocated metric. Six studies' results varied based on the metric used for evaluation and the proposed metric produced results that differed from those originally published in two of the studies. Standardizing metrics to accurately reflect the rate of information transmission is critical to properly evaluate and compare BCI communication systems and advance the field in an unbiased manner
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Assessment of Heart Failure Patients' Interest in Mobile Health Apps for Self-Care: Survey Study.
BackgroundHeart failure is a serious public health concern that afflicts millions of individuals in the United States. Development of behaviors that promote heart failure self-care may be imperative to reduce complications and avoid hospital re-admissions. Mobile health solutions, such as activity trackers and smartphone apps, could potentially help to promote self-care through remote tracking and issuing reminders.ObjectiveThe objective of this study was to ascertain heart failure patients' interest in a smartphone app to assist them in managing their treatment and symptoms and to determine factors that influence their interest in such an app.MethodsIn the clinic waiting room on the day of their outpatient clinic appointments, 50 heart failure patients participated in a self-administered survey. The survey comprised 139 questions from previously published, institutional review board-approved questionnaires. The survey measured patients' interest in and experience using technology as well as their function, heart failure symptoms, and heart failure self-care behaviors. The Minnesota Living with Heart Failure Questionnaire (MLHFQ) was among the 11 questionnaires and was used to measure the heart failure patients' health-related quality of life through patient-reported outcomes.ResultsParticipants were aged 64.5 years on average, 32% (16/50) of the participants were women, and 91% (41/45) of the participants were determined to be New York Heart Association Class II or higher. More than 60% (30/50) of the survey participants expressed interest in several potential features of a smartphone app designed for heart failure patients. Participant age correlated negatively with interest in tracking, tips, and reminders in multivariate regression analysis (P<.05). In contrast, MLHFQ scores (worse health status) produced positive correlations with these interests (P<.05).ConclusionsThe majority of heart failure patients showed interest in activity tracking, heart failure symptom management tips, and reminder features of a smartphone app. Desirable features and an understanding of factors that influence patient interest in a smartphone app for heart failure self-care may allow researchers to address common concerns and to develop apps that demonstrate the potential benefits of mobile technology
Bidirectional Representation Learning from Transformers using Multimodal Electronic Health Record Data to Predict Depression
Advancements in machine learning algorithms have had a beneficial impact on
representation learning, classification, and prediction models built using
electronic health record (EHR) data. Effort has been put both on increasing
models' overall performance as well as improving their interpretability,
particularly regarding the decision-making process. In this study, we present a
temporal deep learning model to perform bidirectional representation learning
on EHR sequences with a transformer architecture to predict future diagnosis of
depression. This model is able to aggregate five heterogenous and
high-dimensional data sources from the EHR and process them in a temporal
manner for chronic disease prediction at various prediction windows. We applied
the current trend of pretraining and fine-tuning on EHR data to outperform the
current state-of-the-art in chronic disease prediction, and to demonstrate the
underlying relation between EHR codes in the sequence. The model generated the
highest increases of precision-recall area under the curve (PRAUC) from 0.70 to
0.76 in depression prediction compared to the best baseline model. Furthermore,
the self-attention weights in each sequence quantitatively demonstrated the
inner relationship between various codes, which improved the model's
interpretability. These results demonstrate the model's ability to utilize
heterogeneous EHR data to predict depression while achieving high accuracy and
interpretability, which may facilitate constructing clinical decision support
systems in the future for chronic disease screening and early detection.Comment: in IEEE Journal of Biomedical and Health Informatics (2021
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Developing a real-time translator from neural signals to text: An articulatory phonetics approach
New developments in brain-computer interfaces (BCI) harness machine learning to decode spoken language from electrocorticographic (ECoG) and local field potential (LFP) signals. Orienting to signals associated with motor movements that produce articulatory features improves phoneme detection quality: individual phonemes share features, but possess a unique feature set; classification by feature set allows for a finer distinction between neural signals. Data indicates vowels are more detectable, consonants have greater detection accuracy, place of articulation informs precision, and manner of articulation affects recall. Findings have implications for the multisensory integration of speech and the role of motor imagery in phonemic neural representations
A Multi-resolution Model for Histopathology Image Classification and Localization with Multiple Instance Learning
Histopathological images provide rich information for disease diagnosis.
Large numbers of histopathological images have been digitized into high
resolution whole slide images, opening opportunities in developing
computational image analysis tools to reduce pathologists' workload and
potentially improve inter- and intra- observer agreement. Most previous work on
whole slide image analysis has focused on classification or segmentation of
small pre-selected regions-of-interest, which requires fine-grained annotation
and is non-trivial to extend for large-scale whole slide analysis. In this
paper, we proposed a multi-resolution multiple instance learning model that
leverages saliency maps to detect suspicious regions for fine-grained grade
prediction. Instead of relying on expensive region- or pixel-level annotations,
our model can be trained end-to-end with only slide-level labels. The model is
developed on a large-scale prostate biopsy dataset containing 20,229 slides
from 830 patients. The model achieved 92.7% accuracy, 81.8% Cohen's Kappa for
benign, low grade (i.e. Grade group 1) and high grade (i.e. Grade group >= 2)
prediction, an area under the receiver operating characteristic curve (AUROC)
of 98.2% and an average precision (AP) of 97.4% for differentiating malignant
and benign slides. The model obtained an AUROC of 99.4% and an AP of 99.8% for
cancer detection on an external dataset.Comment: 9 pages, 6 figure
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